Monoclonal Antibody to Cyclin D1 (Clone: ABM47F5)
Cyclin D1 (CCND1) is an important positive regulator of the G1/S phase of the cell cycle. It regulate cell cycle transition from G1 phase to S phase It is a well-established human oncogene which is frequently amplified or overexpressed in cancers (25409185) . Cyclin D1b is one of two proteins translated from Cyclin D1 transcripts (isoforms a and b) that are generated due to gene polymorphism. Low Cyclin D1b expression in cervical cancer tissue, with an expression level in moderately or poorly differentiated tissues was significantly lower than that in well-differentiated tissues (25120779) . Diseases associated with CCND1 include multiple myeloma and mantle cell lymphoma.
Product Specifications
Product Name Alternative
CCND1||DIP1||GCIP||HHM
Gene Name
CCND1
Gene ID
595
UniProt
P24385
Host
Mouse
Reactivity
Human
Immunogen
A partial length recombinant Cyclin D1 protein (amino acids 107-275) was used as the immunogen for this antibody.
Target Antigen
Cyclin D1
Clonality
Monoclonal
Clone
ABM47F5
Applications
IHC
Purification
Protein G Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Immunohistochemical analysis: 5-10 μg/mL
Isotype
Mouse IgG2a Kappa
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