Monoclonal Antibody to Cyclin D1 (Clone: ABM47F5)

Cyclin D1 (CCND1) is an important positive regulator of the G1/S phase of the cell cycle. It regulate cell cycle transition from G1 phase to S phase It is a well-established human oncogene which is frequently amplified or overexpressed in cancers (25409185) . Cyclin D1b is one of two proteins translated from Cyclin D1 transcripts (isoforms a and b) that are generated due to gene polymorphism. Low Cyclin D1b expression in cervical cancer tissue, with an expression level in moderately or poorly differentiated tissues was significantly lower than that in well-differentiated tissues (25120779) . Diseases associated with CCND1 include multiple myeloma and mantle cell lymphoma.