Monoclonal Antibody to MLH1 (Clone: ABM4D74)
MutL homolog 1 (MLH1) is a member of mismatch repair genes (MMR) that plays a crucial role in correcting replication errors, cell cycle arrest, apoptosis and oxidative stress. MLH1 is a human homolog of the E.coli DNA mismatch repair gene. It mediates protein-protein interactions during mismatch recognition, strand discrimination, and strand removal. Diseases associated with MLH1 include colorectal cancer, hereditary nonpolyposis, type 2 and lynch syndrome.
Product Specifications
Product Name Alternative
MLH1||COCA2
Gene Name
MLH1
Gene ID
4292
UniProt
P40692
Host
Mouse
Reactivity
Human
Immunogen
A partial length recombinant MLH1 protein (amino acids 289-492) was used as the immunogen for this antibody.
Target Antigen
MLH1
Clonality
Monoclonal
Clone
ABM4D74
Applications
IHC
Purification
Protein G Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Immunohistochemical analysis: 5-10μg/mL
Isotype
Mouse IgG2b
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