Monoclonal Antibody to Endoglin (Clone: ABM46D3)
ENG (Endoglin) is an integral membrane glycoprotein that serves as a co receptor for members of the transforming growth factor-beta superfamily of proteins. It is a type I membrane glycoprotein expressed as a disulfide-linked homodimer on human vascular endothelial cells and is implicated in a dominant vascular dysplasia known as hereditary hemorrhagic telangiectasia as well as in preeclampsia. Endoglin suppresses human prostate cancer (PCa) cell invasion. It has been identified as a candidate tumor-suppressor gene in esophageal squamous cell carcinoma (ESCC) .
Product Specifications
Product Name Alternative
ENG||END
Gene Name
ENG
Gene ID
2022
UniProt
P17813
Host
Mouse
Reactivity
Human
Immunogen
A partial length recombinant Endoglin protein (amino acids 43-287) was used as the immunogen for this antibody.
Target Antigen
Endoglin
Clonality
Monoclonal
Clone
ABM46D3
Applications
WB
Purification
Protein G Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Western blot analysis: 4-6 μg/mL
Isotype
Mouse IgG1 Kappa
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