Monoclonal Antibody to PAPP-A (Clone: ABM4C62)
PAPP-A (pregnancy-associated plasma protein A) is a zinc metalloproteinase in the insulin-like growth factor system that is expressed by tissues outside of pregnancy and involved in normal and dysregulated growth. It has prognostic impact in pregnancy and acute coronary syndrome. PAPP-A regulate the activity of insulin-like growth factor (IGF) signal pathway through proteolytic degradation of IGF binding proteins (IGFBPs) thereby increasing the local concentration of free IGFs available to receptors. PAPP-A levels is associated with abnormal glucose metabolism and increased risk of atherosclerosis in AGHD (Adult Growth Hormone Deficiency) patients.
Product Specifications
Product Name Alternative
Insulin-like growth factor-dependent IGF-binding protein 4 protease, IGF-dependent IGFBP-4 proteas, Pregnancy-associated plasma protein A
Gene Name
PAPPA
Gene ID
5069
UniProt
Q13219
Host
Mouse
Reactivity
Human
Immunogen
A partial length recombinant PAPP-A protein (amino acids 332-561) was used as the immunogen for this antibody.
Target Antigen
PAPP-A
Clonality
Monoclonal
Clone
ABM4C62
Applications
IHC
Purification
Protein G Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Immunohistochemical analysis: 5-10 μg/mL
Isotype
Mouse IgG2b Kappa
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