Monoclonal Antibody to Napsin A (Clone: ABM4H60)
Napsin A, a human aspartic proteinase is found primarily in type II pneumocytes and alveolar macrophages and predominantly expressed in lung and kidney. It is a reliable marker for pulmonary adenocarcinoma and is expressed in a subset of ovarian clear cell carcinomas (O-CCCs), endometrial (EM) CCCs, and endometrioid carcinomas (EC) . It is also useful in evaluating SH (Sclerosing hemangiomas) (23194051) . Napsin A acts as an anti-apoptotic protein that promotes resistance to cisplatin by degradation of the tumor suppressor p53, which is regulator of the cell cycle and co-works with cyclin kinase inhibitors as p21 and p27.
Product Specifications
Product Name Alternative
NAPSA||NAP1||NAPA
Gene Name
NAPSA
Gene ID
9476
UniProt
O96009
Host
Mouse
Reactivity
Human
Immunogen
A partial length recombinant Napsin protein (amino acids 150-350) was used as the immunogen for this antibody
Target Antigen
Napsin
Clonality
Monoclonal
Clone
ABM4H60
Applications
IHC, WB
Purification
Protein G Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Western blot analysis: 2-4 μg/mL; Immunohistochemical analysis: 5-10 μg/mL
Isotype
Mouse IgG1 Kappa
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