Monoclonal Antibody to SOX11 (Clone: ABM45D9)

SOX11 (Sex determining region Y-box 11), located on chromosome 2p25, belong to the family of genes SOXC. It is a transcript factor involved in the embryonic neurogenesis and tissue remodeling, also participating in the control of cell proliferation. It is involved in gastrulation and in malignant diseases. It is expressed in foetal and neoplastic brain tissue, including gliomas (23619925) . SOX11 is overexpressed in several solid tumors and in the vast majority of aggressive mantle cell lymphomas (MCLs) . Diseases associated with SOX11 include mental retardation, autosomal dominant, 27 and coffin-siris syndrome.