Monoclonal Antibody to c-erbB-2/Her2 (Clone: ABM45F5)
HER2, a known proto-oncogene, is located at the long arm of human chromosome 17 (17q12), encoding a type 1 tyrosine kinase growth factor receptor and the role of HER2 in the development of numerous types of human cancer. HER2 is a transmembrane receptor comprising an extracellular domain (ECD), a single transmembrane domain, and an intracellular domain (ICD) with tyrosine-kinase activity.The high-expression and amplification of C-erbB-2 and its protein products (P185) are found in a wide variety of tumors. HER2 is overexpressed in 10% to 35% of gastric and gastroesophageal junction (GEJ) adenocarcinomas.
Product Specifications
Product Name Alternative
ERBB2||HER2||MLN19||NEU||NGL
Gene Name
ERBB2
Gene ID
2064
UniProt
P04626
Host
Mouse
Reactivity
Human
Immunogen
A partial length protein (amino acids 301-522) was used as the immunogen for this antibody (from extra cellular domain of c-erbB-2) .
Target Antigen
C-erbB-2/Her2
Clonality
Monoclonal
Clone
ABM45F5
Applications
IHC
Purification
Protein G Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Immunohistochemical analysis: 5-10μg/mL
Isotype
Mouse IgG2b Kappa
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