Monoclonal Antibody to BCL-6 (Clone: ABM44G9)
BCL6 (B-cell lymphoma 6) is a 95 kDa zinc finger transcription factor and contains an N-terminal POZ domain. BCL6 is a transcriptional repressor and a master regulator of the germinal center (GC) B cell phenotype controlling its development and growth. BCL-6 modulates IL-4, BCR, and CD40L signals for normal B cell development. Altered BCL6 protein expression is implicated in pathogenesis of diverse human hematologic malignancies, especially in the diffuse large B cell lymphoma (DLBCL), the most common lymphoma in adults. BCL6 suppresses the expression of p53 (also known as tp53) tumor suppressor gene and modulates DNA damage-induced apoptotic responses in GC B cells.
Product Specifications
Product Name Alternative
BCL6||BCL5||LAZ3||ZBTB27||ZNF51
Gene Name
BCL6
Gene ID
604
UniProt
P41182
Host
Mouse
Reactivity
Human
Immunogen
A partial length recombinant BCL-6 protein (amino acids 200-401) was used as the immunogen for this antibody.
Target Antigen
BCL-6
Clonality
Monoclonal
Clone
ABM44G9
Applications
WB
Purification
Protein G Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Western blot analysis: 2-4μg/mL
Isotype
Mouse IgG2b Kappa
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