Monoclonal Antibody to CDC25A (Clone: ABM4A46)
CDC25A is a dual specificity (tyr/thr) phosphatase and a putative upregulated c-Myc target gene. It is a regulator of the cell cycle required for progression from G1 to S phase. CDC25A is a member of the CDC25 family of phosphatases. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. Overexpression of CDC25A bypassed the mechanism of cell cycle arrest, leading to enhanced DNA damage and decreased cell survival. Specific degradation of CDC25A is identified as part of the DNA damage checkpoint mechanism and suggested how CDC25A overexpression in human cancers might contribute to tumorigenesis.
Product Specifications
Product Name Alternative
CDC25A
Gene Name
CDC25A
Gene ID
993
UniProt
P30304
Host
Mouse
Reactivity
Human
Immunogen
A partial length recombinant CDC25A protein (amino acids 190-484) was used as the immunogen for this antibody.
Target Antigen
CDC25A
Clonality
Monoclonal
Clone
ABM4A46
Applications
IHC, WB
Purification
Protein G Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Western blot analysis: 2-4μg/mL, Immunohistochemical analysis: 5μg/mL
Isotype
Mouse IgG2b Kappa
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