Monoclonal Antibody to IDH1 (Clone: ABM44B3)
Isocitrate dehydrogenase 1 (IDH1) is a dimeric cytosolic NADP-dependent dehydrogenase that catalyzes decarboxylation of isocitrate into alpha-ketoglutarate. It belongs to two distinct subclasses, one of which utilizes NAD (+) as the electron acceptor and the other NADP (+) . It serves a significant role in cytoplasmic NADPH production. It is found in the cytoplasm and peroxisomes. IDH1 is of great importance in cell metabolism and energy conversion. Mutations in IDH1 are found in a somatic mosaic fashion in patients with multiple enchondromas.
Product Specifications
Product Name Alternative
IDH1||PICD
Gene Name
IDH1
Gene ID
3417
UniProt
O75874
Host
Mouse
Reactivity
Human
Immunogen
A partial length recombinant IDH1 protein (amino acids 198-414) was used as the immunogen for this antibody
Target Antigen
IDH1
Clonality
Monoclonal
Clone
ABM44B3
Applications
IHC
Purification
Protein G Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Immunohistochemical analysis: 5μg/mL
Isotype
Mouse IgG2a Kappa
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