Monoclonal Antibody to HGAL (Clone: ABM43E6)

Human germinal center-associated lymphoma (HGAL) is specifically expressed only in germinal center (GC), B lymphocytes and GC-derived lymphomas. It is located on chromosome 3q13, comprises 6 exons and encodes a cytoplasmic protein of 178 amino acids that contains an immunoreceptor tyrosine-based activation motif (ITAM) . HGAL decreases lymphocyte motility by inhibiting the ability of myosin to translocate actin via direct interaction with F-actin and myosin II and by activating RhoA signaling via direct interactions with RhoA-specific guanine nucleotide exchange factors. It also regulates B-cell receptor (BCR) signaling by directly binding to and enhancing Syk kinase activity and activation of its downstream effectors (Ref-1) . HGAL expression by tumor cells correlates with a favorable prognosis in patients with diffuse large B-cell and classical Hodgkin lymphomas.