Monoclonal Antibody to DNMT2 (Clone: ABM1H70)
DNMT2, also known as tRNA-aspartic acid methyltransferase 1 (TRDMT1), is highly conserved cytosine-C5 methyltransferase that introduces the C38 methylation of tRNAAsp in many species, including lower eukaryotes, plants, insects, and humans. DNMT2 contains all 10 sequence motifs that are conserved among m5C MTases, including the consensus S-adenosyl-L-methionine-binding motifs and the active site ProCys dipeptide. It is a relatively small protein of 391 amino acids and lacks the large N-terminal domains present in the DNMT1 and DNMT3 families. DNMT2 is ubiquitously expressed with multiple mRNA species in most human and mouse adult tissues. It is variably expressed in human cancer cell lines.
Product Specifications
Product Name Alternative
DNA (cytosine-5) -methyltransferase-like protein 2, DNA methyltransferase homolog HsaIIP, DNMT2
Gene Name
TRDMT1
Gene ID
1787
UniProt
O14717
Host
Mouse
Reactivity
Mouse, Human
Immunogen
A partial length recombinant protein from DNMT2 was used as the immunogen for this antibody.
Target Antigen
DNMT2
Clonality
Monoclonal
Clone
ABM1H70
Applications
FACS, WB
Purification
Protein G Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
WB: 4-6 μg/mL, FACS: 0.5-1 μg/10^6
Isotype
Mouse IgG1, Kappa
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