Monoclonal antibody to CD46 (Clone: TRA-2-10)

CD46 is a transmembrane protein that serves several functions, including as a complement membrane cofactor protein (MCP) and a receptor to the measles virus. CD46 is widely expressed on leukocytes, platelets, epithelial cells, and fibroblasts. There are multiple reported isoforms of CD46 with molecular weights ranging from 45 to 75 kD. The CD46 protein binds and inactivates the complement components C3b and C4b and ahs also been reported to play a role in T cell regulation. In addition, CD46 has been shown to interact with other proteins, including moesin, c-SRC, tetraspanin 4, c-Yes, and integrin delta21. CD46 also acts as a cellular receptor for human herpes virus-6 and human measles virus, in addition to other pathogens such as Streptococcus pyogenes. Defective CD46 has been associated with hemolytic-uremic syndrome.