Monoclonal antibody to CD68 (Clone: ABM53F5)
CD68 is a transmembrane glycoprotein which acts as a commercialized marker for human monocytes and macrophages. Its expression is thought to be regulated by a macrophage-specific promoter. However, several immunohistochemical studies have indicated that CD68 antibodies also react with other haematopoietic and non-haematopoietic cell types. It also can stain myeloid cells, dendritic cells, fibroblasts, Langerhans cells and others. In human monocytes, which produce high levels of CD68 mRNA, the gene is characterized by intramolecular ligations between the promoter and the 3' intervening region. CD68 is also used as a pan-macrophage marker for TAM (Tumor-Associated Macrophages) which always involve in carcinogenesis.
Product Specifications
Product Name Alternative
Macrosialin, Gp110
Gene Name
CD68
Gene ID
968
UniProt
P34810
Host
Mouse
Reactivity
Human
Immunogen
A partial length recombinant protein (a.a 80-280) of CD68 was used as the immunogen for this antibody.
Target Antigen
CD68
Clonality
Monoclonal
Clone
ABM53F5
Applications
FACS, WB
Purification
Protein G Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
FACS: 0.5-1 μg/10^6 cells, WB: 2-4 μg/mL
Isotype
Mouse IgG2b, kappa
Conjugate
Unconjugated
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