Monoclonal Antibody to IL-36R (Clone: ABM47A2)
IL-36R is a member of the IL-1 receptor family that has been associated with various inflammation-associated diseases. Ligands binding to IL-36R subsequently recruit the IL-1RAcP (IL-1 Receptor Accessory Protein) forming a heterodimeric signaling complex. The latter is also used by IL-1Alpha and IL-1Beta. IL-36R is expressed by different immune cells, including Dendritic Cells, microglia and other myeloid cells. IL-36 stimulation of DC leads to the production of several cytokines by DC, including TNF-a, IL-1, IL-12, and IL-23. This interaction also enhances the expression of MHC class 2 and co-stimulatory molecules.
Product Specifications
Product Name Alternative
IL1RL2||IL1RRP2
Gene Name
IL1RL2
Gene ID
8808
UniProt
Q9HB29
Host
Mouse
Reactivity
Human
Immunogen
A partial length recombinant IL-36R protein (amino acids 1-203) was used as the immunogen for this antibody.
Target Antigen
IL-36R
Clonality
Monoclonal
Clone
ABM47A2
Applications
FACS, WB
Purification
Protein G Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Western blot analysis: 2-4 μg/mL, Flowcytometric analysis: 0.5-1 μg/10^6 Cells
Isotype
Mouse IgG2b, kappa
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