Monoclonal Antibody to MUL1 (Clone: ABM4F71)
MUL1 (Mitochondrial E3 Ubiquitin Protein Ligase-1) is a crucial moderator of RIG-I (Retinoic Acid-Inducible-Gene-I) signaling. This protein is localized to the mitochondria where it interacts with MAVS (Mitochondrial Antiviral Signaling) and catalyzes RIG-I post-translational modifications that inhibit RIG-I-dependent cell signaling. MUL1 contains a unique BAM (Beside A Membrane) domain and a C-terminal RING-finger domain. This protein has been implicated in several processes that occur in animal cells such as NF-KappaB activation, innate immunity and antiviral signaling, suppression of PINK1/parkin defects, mitophagy in skeletal muscle, and caspase-dependent apoptosis.
Product Specifications
Product Name Alternative
MUL1||C1orf166||GIDE||MAPL||MULAN||RNF218
Gene Name
MUL1
Gene ID
79594
UniProt
Q969V5
Host
Mouse
Reactivity
Human
Immunogen
A partial length recombinant MUL1 protein (amino acids 146-352) was used as the immunogen for this antibody.
Target Antigen
MUL1
Clonality
Monoclonal
Clone
ABM4F71
Applications
WB
Purification
Protein G Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Western blot analysis: 4-8 μg/mL
Isotype
Mouse IgG1, kappa
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