Monoclonal Antibody to CD20 (Clone: ABM46C7)
CD20 is clinically validated as an immunotherapy target for B-cell lymphomas and autoimmune diseases. CD20 consists of large, intracellular, amino- and carboxyterminal portions connected by 4 membrane-spanning domains. Its high expression on malignant B cells and its reported lack of shedding from the surfacemake CD20 an ideal target for antibody-mediated killing. Anti-CD20 antibodies are believed to mediate the therapeutic effect by activation of complement-dependent cytotoxicity (CDC) and largely by antibody-dependent cellular cytotoxicity exerted by recruitment of innate immune effector cells expressing the Fcgamma receptor IIIa.
Product Specifications
Product Name Alternative
MS4A1||CD20
Gene Name
MS4A1
Gene ID
931
UniProt
P11836
Host
Mouse
Reactivity
Human
Immunogen
A partial length recombinant protein corresponding to extra cellular domain of CD20 was used as the immunogen for this antibody.
Target Antigen
CD20
Clonality
Monoclonal
Clone
ABM46C7
Applications
FACS, WB
Purification
Protein G Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Western blot analysis: 2-4 μg/mL FACS : 0.5 μg / 10^6 cells
Isotype
Mouse IgG2b Kappa
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