Monoclonal Antibody to Human CD33 (Clone: wm53)
CD33 is a member of the SIGLEC (Sialic Acid-Binding Ig-Like Lectin) family of receptors, and the gene comprises seven coding exons. Exon 2 encodes the canonical IgV domain, exon 4 encodes the IgC structural domain, and exons 6 and 7 encode cytosolic ITIMs (Immunotyrosine Inhibitory Motifs) . CD33 acts as a cell surface antigen which is expressed on normal myeloid cells and CD34+ blasts in AML (Acute Myeloid Leukemia) . The antigen serves as a target of GO (Gemtuzumab/Ozogamicin), which exerts anti-leukemic effects in refractory AML.
Product Specifications
Product Name Alternative
Myeloid cell surface antigen CD33||Sialic acid-binding Ig-like lectin 3||Siglec-3||gp67
Gene Name
CD33
Gene ID
945
UniProt
P20138
Host
Mouse
Reactivity
Human
Immunogen
Human AML cells were used as immunogen for this antibody.
Target Antigen
CD33
Clonality
Monoclonal
Clone
Wm53
Applications
FACS
Purification
Protein G Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
FACS: 0.5-1 μg/10^6 cells
Isotype
Mouse IgG1 Kappa
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