Monoclonal Antibody to Mouse CD3 (Clone: 145-2C11)
CD3 is one of the several invariant chains that the variable chains of TCR: Alpha beta or Gamma delta TCR contains, and which support surface TCR expression and transduce the TCR signal. CD3D, along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK) .
Product Specifications
Product Name Alternative
T-cell surface glycoprotein CD3 zeta chain||T-cell receptor T3 zeta chain||CD247
Gene Name
Cd247
Gene ID
12503
UniProt
P24161
Host
Hamster
Reactivity
Mouse
Immunogen
Mouse BM10-37 cytotoxic T lymphocytes were used as immunogen for this antibody.
Target Antigen
CD3
Clonality
Monoclonal
Clone
145-2C11
Applications
FACS
Purification
Protein G Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
FACS: 0.5-1 μg/10^6 cells
Isotype
Hamster IgG
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