Monoclonal Antibody to CD33 (Clone: ABM29D3)
CD33 is a member of the SIGLEC (Sialic Acid-Binding Ig-Like Lectin) family of receptors, and the gene comprises seven coding exons. Exon 2 encodes the canonical IgV domain, exon 4 encodes the IgC structural domain, and exons 6 and 7 encode cytosolic ITIMs (Immunotyrosine Inhibitory Motifs) . CD33 acts as a cell surface antigen which is expressed on normal myeloid cells and CD34+ blasts in AML (Acute Myeloid Leukemia) . The antigen serves as a target of GO (Gemtuzumab/Ozogamicin), which exerts anti-leukemic effects in refractory AML.
Product Specifications
Product Name Alternative
CD33||SIGLEC3
Gene Name
CD33
Gene ID
945
UniProt
P20138
Host
Mouse
Reactivity
Human
Immunogen
A partial length recombinant CD33 protein (amino acids 28-320) was used as the immunogen for this antibody.
Target Antigen
CD33
Clonality
Monoclonal
Clone
ABM29D3
Applications
IHC, FACS, WB
Purification
Protein G Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Western blot analysis: 2-4 μg/mL, Immunohistochemical analysis: 5 μg/mL FACS: 0.2-0.5 μg/10^6 cells
Isotype
Mouse IgG2a Kappa
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