Monoclonal Antibody to TSLP Receptor (Clone: ABM28B6)
TSLPR (thymic stromal lymphopoietin receptor) also known as CRLF2 (cytokine receptor-like factor 2) is a member of type I cytokine receptor. It binds its ligand TSLP (thymic stromal lymphopoietin) as a heterodimer with IL7R. TSLP ligand is produced by epithelial cells in order to activate dendritic cells, and is involved in inflammation, allergic responses as well as B-cell precursor proliferation and survival. The interaction between TSLP and its heterodimeric receptor activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. High expression of CRLF2 is associated with a poor prognosis in adult and high-risk pediatric cases of B-ALL (B-cell acute lymphoblastic leukemias) .
Product Specifications
Product Name Alternative
CRLF2||CRL2||ILXR||TSLPR
Gene Name
CRLF2
Gene ID
64109
UniProt
Q9HC73
Host
Mouse
Reactivity
Human
Immunogen
A partial length recombinant TSLPR protein (amino acids 97-252) was used as the immunogen for this antibody.
Target Antigen
TSLP Receptor
Clonality
Monoclonal
Clone
ABM28B6
Applications
FACS, WB
Purification
Protein G Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Western blot analysis: 2-4 μg/mL, Flowcytometric analysis: 0.5-1 μg/10^6 Cells
Isotype
Mouse IgG2a Kappa
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