Monoclonal Antibody to IL-23R (Clone: ABM25G4)
IL-23, a member of the IL-12 cytokine family, is composed of a p40 subunit, which is shared with IL-12, and a p19 subunit, with an approximate molecular weight of 60 kDa. IL-23 is produced by activated dendritic cells and macrophages in response to microorganisms. IL-23 promotes Th17 cells producing TNF-a, IL-17, IL-6, IL-22, GM-CSF, and other novel factors, which are associated with the induction of autoimmune inflammation. IL-23 is essential for Th17 differentiation, expansion, and survival by binding to its receptor, thereby activating the signaling pathway. Many studies revealed that the IL-23/Th17 pathway is implicated in the pathophysiology of various autoimmune diseases, such as autoimmune arthritis, primary biliary cirrhosis, and inflammatory bowel disease.
Product Specifications
Product Name Alternative
Interleukin-23 receptor, IL-23 receptor, IL-23R
Gene Name
IL23R
Gene ID
149233
UniProt
Q5VWK5
Host
Mouse
Reactivity
Human
Immunogen
A partial length recombinant protein (a.a 250-450) of IL-23R was used as the immunogen for this antibody.
Target Antigen
IL-23R
Clonality
Monoclonal
Clone
ABM25G4
Applications
FACS, WB
Purification
Protein G Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Western blot analysis: 1-2 μg/mL, Flowcytometric analysis: 2-4 μg/10^6 cells
Isotype
Mouse IgG1, Kappa
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