Monoclonal Antibody to TLR7 (Clone: ABM2C27)
TLR7 (Toll-like receptor 7) is a member of the Toll-like receptor (TLR) family. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA; which plays a fundamental role in pathogen recognition and activation of innate immunity. TLR7 controls host immune response against pathogens through recognition of molecular patterns specific to microorganisims. TLR7 interacts with MYD88 via their respective TIR domains and also interacts with UNC93B1. Post-translational modifications and glycosylation occur in TLR7. TLR7 detected in brain, placenta, spleen, stomach, small intestine, lungs and plasmacytoid pre-dendritic cells.
Product Specifications
Product Name Alternative
TLR7||UNQ248/PRO285
Gene Name
TLR7
Gene ID
51284
UniProt
Q9NYK1
Host
Mouse
Reactivity
Human
Immunogen
A partial length recombinant human TLR7 protein (amino acids 500-900) was used as the immunogen for this antibody.
Target Antigen
TLR7
Clonality
Monoclonal
Clone
ABM2C27
Applications
IHC, FACS
Purification
Protein G Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
FACS analysis: 0.5 μg/10^6 cells, Immunohistochemical analysis: 5 μg/mL
Isotype
Mouse IgG1 Kappa
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