Monoclonal Antibody to TLR8/CD288 (Clone: ABM15F6)
Toll like receptor 8, also known as CD288, is a member of TLR family. It plays an important role in sensing phagocytosed pathogen. TLR8 recognizes ssRNA and recruits MyD88 and leads to the activation of transcription factor NF-kappa B. TLR8 TLR8 has two splice variants, viz., TLR8v1 and TLR8v2 and one missense variant, termed G or A1G allele of TLR8. TLR8v1 has additional 19 amino acids in the N-terminus. It is predominantly expressed in lung and peripheral blood leukocytes.
Product Specifications
Product Name Alternative
TLR8||UNQ249/PRO286
Gene Name
TLR8
Gene ID
51311
UniProt
Q9NR97
Host
Mouse
Reactivity
Human
Immunogen
A partial length recombinant TLR8 protein (amino acids 750-900) was used as the immunogen for this antibody.
Target Antigen
TLR8/CD288
Clonality
Monoclonal
Clone
ABM15F6
Applications
IHC, FACS
Purification
Protein G Chromatography
Format
Purified
Components
25 μg in 50 μl/100 μg in 200 μl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage Conditions
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Applications Notes
Immunohistochemical analysis: 5 μg/mL; FACS analysis: 2 μg/10^6 cells
Isotype
Mouse IgG1 Kappa
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