Dynarrestin
Dynarrestin is an aminothiazole inhibitor of cytoplasmic dynein (cytoplasmic dynein) 1 and 2 and can be used to probe cytoplasmic dynein-dependent cellular processes. Dynarrestin rapidly and reversibly inhibits dynamin-1-driven microtubule sliding in vitro and disrupts mitosis by inducing spindles. Dynarrestin does not affect ATP hydrolysis and interferes with ciliogenesis. Dynarrestin inhibits hedgehog (Hh) -dependent proliferation of neuronal precursors and tumor cells.
Product Specifications
CAS Number
2222768-84-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Hedgehog
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dynarrestin.html
Purity
98.18
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
O=C(C1=C(C2=CC=C(N(CC)CC)C=C2)N=C(NC3=CC=C(F)C=C3F)S1)OCC
Molecular Formula
C22H23F2N3O2S
Molecular Weight
431.50
Precautions
H302, H315, H319, H335
References & Citations
[1]Höing S, et al. Dynarrestin, a Novel Inhibitor of Cytoplasmic Dynein. Cell Chem Biol. 2018 Apr 19;25 (4) :357-369.e6.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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