Furegrelate (sodium)
Furegrelate Sodium (U-63557A) is a potent, orally available, and selective thromboxane synthase inhibitor. Furegrelate Sodium inhibits human platelet microsomal thromboxane A2 (TxA2) synthase with an IC50 of 15 nM. Furegrelate Sodium is being developed as an antiplatelet agent[1][2].
Product Specifications
CAS Number
85666-17-7
Product Name Alternative
U-63557A
UNSPSC
12352005
Target
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/furegrelate-sodium.html
Purity
99.82
Solubility
DMSO : 13 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC2=CC(CC3=CC=CN=C3)=CC=C2O1)O[Na]
Molecular Formula
C15H10NNaO3
Molecular Weight
275.23
References & Citations
[1]Gorman RR, et al. Inhibition of platelet thromboxane A2 synthase activity by sodium 5- (3'-pyridinylmethyl) benzofuran-2-carboxylate. Prostaglandins. 1983 Aug;26 (2) :325-42.|[2]Hirenallur-S DK, et al. Furegrelate, a thromboxane synthase inhibitor, blunts the development of pulmonary arterial hypertension in neonatal piglets. Pulm Circ. 2012 Apr-Jun;2 (2) :193-200.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
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