Protonstatin-1

Protonstatin-1 is a selective plasma membrane (PM) H+-ATPase inhibitor (IC50 of 3.9 μM) that inhibits auxin transport. Protonstatin-1 interacts with the PM H+-ATPase central loop and may thus impede the functions of the N- and/or P-domain to inhibit the pump activity[1][2].

Product Specifications

CAS Number

[521972-99-6]

UNSPSC

12352005

Hazard Statement

H317, H319

Target

Proton Pump

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/protonstatin-1.html

Concentration

10mM

Purity

98.47

Solubility

DMSO : 70 mg/mL (ultrasonic)

Smiles

O=C1NC(S/C1=C\C2=CC=CO2)=S

Molecular Formula

C8H5NO2S2

Molecular Weight

211.26

Precautions

H317, H319

References & Citations

[1]Yongqing Yang, et al. Testing the polar auxin transport model with a selective plasma membrane H+ -ATPase inhibitor. J Integr Plant Biol. 2022 Jun;64 (6) :1229-1245.|[2]Yongqing Yang, et al. Screening of protonstatin-1 (PS-1) analogs for improved inhibitors of plant plasma membrane H+-ATPase activity. Front Plant Sci. 2022 Oct 12:13:973471.