5-Hydroxymethyl-2'-deoxycytidine-5'-Triphosphate

Methylated deoxycytidine analogs are well studied epigenetic modifications. 5-Hydroxymethyl-2'-deoxycytidine has recently been discovered in mammalian genomic DNA, but is substantially depleted in many types of human cancers. A strong inverse relationship has been demonstrated between the proliferation rate of cells and the global level of 5-hydroxymethyl-2'-deoxycytidine in both porcine and rat tissues, but no such relationship was observed for 5-formyl-2'-deoxycytidine and 5-carboxyl-2'-deoxycytidine.

Product Specifications

Applications

Aptamers, Epigenetics/DNA Damage, In vitro Transcription, Mutagenesis, Photocrosslinking Studies

Concentration

100 mM

Purity

≥90% by AX-HPLC

Form

Li+

Buffer

H2O

Molecular Formula

C10H18N3O14P3 (free acid)

Molecular Weight

497.10 g/mole (free acid)

Shipping Conditions

Frozen

Storage Conditions

-20°C or below

Applications Notes

Products are for research use only, not for use in diagnostic or therapeutic procedures or for use in humans. Products are not for resale without express written permission from TriLink No license under any patent or other intellectual property right of TriLink or its licensors is granted or implied by the purchase unless otherwise provided in writing.