ICI-199441 (hydrochloride)

ICI-199441 hydrochloride is a potent and selective κ-opioid receptor agonist with analgesic effects. ICI 199441 hydrochloride can improve heart resistance to ischemia/reperfusion[1][2].

Product Specifications

CAS Number

[115199-84-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Opioid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/ici-199441.html

Purity

99.30

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C(N(C)[C@@H](C1=CC=CC=C1)CN2CCCC2)CC3=CC=C(Cl)C(Cl)=C3.Cl

Molecular Formula

C21H25Cl3N2O

Molecular Weight

427.80

Precautions

H302, H315, H319

References & Citations

[1]Tsibulnikov SY, et al. Prospects of Using of κ-Opioid Receptor Agonists U-50,488 and ICI 199,441 for Improving Heart Resistance to Ischemia/Reperfusion. Bull Exp Biol Med. 2015;159 (6) :718-721.|[2]Narita M, et al. Chronic pain induces anxiety with concomitant changes in opioidergic function in the amygdala. Neuropsychopharmacology. 2006 Apr;31 (4) :739-50.