BV6

BV6 is an antagonist of cIAP1 and XIAP, members of the inhibitors of apoptosis (IAP) family.

Product Specifications

CAS Number

[1001600-56-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

IAP

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/BV6.html

Concentration

10mM

Purity

99.90

Solubility

DMSO : ≥ 100 mg/mL

Smiles

O=C(NCCCCCCNC([C@@H](NC([C@H](CCC1)N1C([C@H](C2CCCCC2)NC([C@H](C)NC)=O)=O)=O)C(C3=CC=CC=C3)C4=CC=CC=C4)=O)[C@@H](NC([C@H](CCC5)N5C([C@H](C6CCCCC6)NC([C@H](C)NC)=O)=O)=O)C(C7=CC=CC=C7)C8=CC=CC=C8

Molecular Formula

C70H96N10O8

Molecular Weight

1205.57

Precautions

H302, H315, H319, H335

References & Citations

[2]Uegaki T, et al. Inhibitor of apoptosis proteins (IAPs) may be effective therapeutic targets for treating endometriosis. Hum Reprod. 2015 Jan;30 (1) :149-58.|[1]Li W, et al. BV6, an IAP antagonist, activates apoptosis and enhances radiosensitization of non-small cell lung carcinoma in vitro. J Thorac Oncol. 2011 Nov;6 (11) :1801-9.