2-Ketoglutaric acid-13C2
Product Specifications
UNSPSC Description
2-Ketoglutaric acid-13C2 is a deuterated labeled 2-Ketoglutaric acid[1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM)[2].
Target Antigen
Endogenous Metabolite; Isotope-Labeled Compounds; Tyrosinase
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease;Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/2-ketoglutaric-acid-13c2.html
Smiles
OC(CC[13C]([13C](O)=O)=O)=O
Molecular Weight
148.08
References & Citations
[1]Huergo LF, et al. The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite. Microbiol Mol Biol Rev. 2015 Dec;79(4):419-35.|[2]Gou L, et al. The effect of alpha-ketoglutaric acid on tyrosinase activity and conformation: Kinetics and molecular dynamics simulation study. Int J Biol Macromol. 2017 Dec;105(Pt 3):1654-1662.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-W013636S4/2-Ketoglutaric-acid-13C2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-W013636S4/
Clinical Information
No Development Reported
CAS Number
123953-28-6
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