2-Ketoglutaric acid-13C2

2-Ketoglutaric acid-13C2 (Alpha-Ketoglutaric acid-13C2) is a 13C labeled 2-Ketoglutaric acid (HY-W013636) [1]. 2-Ketoglutaric acid (Alpha-Ketoglutaric acid) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid is a reversible inhibitor of tyrosinase (IC50=15 mM) [2].

Product Specifications

CAS Number

[123953-28-6]

Product Name Alternative

Alpha-Ketoglutaric acid-13C2

UNSPSC

12352211

Target

Endogenous Metabolite; Isotope-Labeled Compounds; Tyrosinase

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Others

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/2-ketoglutaric-acid-13c2.html

Smiles

OC(CC[13C]([13C](O)=O)=O)=O

Molecular Formula

C3 13C2H6O5

Molecular Weight

148.08

References & Citations

[1]Huergo LF, et al. The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite. Microbiol Mol Biol Rev. 2015 Dec;79 (4) :419-35.|[2]Gou L, et al. The effect of alpha-ketoglutaric acid on tyrosinase activity and conformation: Kinetics and molecular dynamics simulation study. Int J Biol Macromol. 2017 Dec;105 (Pt 3) :1654-1662.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.