Pruvanserin
Pruvanserin (EMD 281014 free acid) is a selective 5-HT2A receptor antagonist. Pruvanserin alleviates tactile allodynia in diabetic rats. Pruvanserin can also be used for research of insomnia[1].
Product Specifications
CAS Number
[443144-26-1]
Product Name Alternative
EMD 281014 (free acid) ; LY 2422347
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pruvanserin.html
Purity
99.27
Solubility
DMSO : ≥ 100 mg/mL
Smiles
N#CC1=CNC2=C1C=CC=C2C(N3CCN(CC3)CCC4=CC=C(C=C4)F)=O
Molecular Formula
C22H21FN4O
Molecular Weight
376.43
Precautions
H302, H315, H319, H335
References & Citations
[1]Abbas A, et al. Pimavanserin tartrate: a 5-HT2A inverse agonist with potential for treating various neuropsychiatric disorders. Expert Opin Pharmacother. 2008 Dec;9 (18) :3251-9. |[2]Mixcoatl-Zecuatl T, et al. A spinal mechanism of action for duloxetine in a rat model of painful diabetic neuropathy. Br J Pharmacol. 2011 Sep;164 (1) :159-69.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
5-HT2 Receptor; α-1 microglobulin
Available Sizes
Curated Selection
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