6-Fluorotryptophan
6-Fluorotryptophan, a competitive inhibitor of tryptophan hydroxylase, produced a transient disruption of sleep in rats chronically implanted with EEG recording electrodes[1].
Product Specifications
CAS Number
7730-20-3
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Tryptophan Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/6-fluorotryptophan.html
Purity
99.55
Solubility
H2O : 4.85 mg/mL (ultrasonic; warming; adjust pH to 2 with HCl; heat to 60°C)
Smiles
NC(CC1=CNC2=C1C=CC(F)=C2)C(O)=O
Molecular Formula
C11H11FN2O2
Molecular Weight
222.22
Precautions
H302, H315, H319, H335
References & Citations
[1]Miwa S, et al. Determination of serotonin turnover in the rat brain using 6-fluorotryptophan. J Neurochem. 1987 May;48 (5) :1577-80. |[2]D Sugden, et al. Changes in the rat sleep-wake cycle produced by DL-6-fluorotryptophan, a competitive inhibitor of tryptophan hydroxylase. Psychopharmacology (Berl) . 1981;74 (4) :369-73.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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