6-Fluorotryptophan

6-Fluorotryptophan, a competitive inhibitor of tryptophan hydroxylase, produced a transient disruption of sleep in rats chronically implanted with EEG recording electrodes[1].

Product Specifications

CAS Number

[7730-20-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Tryptophan Hydroxylase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/6-fluorotryptophan.html

Purity

99.55

Solubility

H2O : 4.85 mg/mL (ultrasonic; warming; adjust pH to 2 with HCl; heat to 60°C)

Smiles

NC(CC1=CNC2=C1C=CC(F)=C2)C(O)=O

Molecular Formula

C11H11FN2O2

Molecular Weight

222.22

Precautions

H302, H315, H319, H335

References & Citations

[1]Miwa S, et al. Determination of serotonin turnover in the rat brain using 6-fluorotryptophan. J Neurochem. 1987 May;48 (5) :1577-80. |[2]D Sugden, et al. Changes in the rat sleep-wake cycle produced by DL-6-fluorotryptophan, a competitive inhibitor of tryptophan hydroxylase. Psychopharmacology (Berl) . 1981;74 (4) :369-73.