Lomerizine dihydrochloride
Lomerizine dihydrochloride is an antagonist of L- and T-type voltagegated calcium channels.
Product Specifications
CAS Number
101477-54-7
Product Name Alternative
KB-2796
UNSPSC
12352005
Hazard Statement
H302, H410
Target
Calcium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Lomerizine_dihydrochloride.html
Purity
99.95
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
COC1=CC=C(CN2CCN(C(C3=CC=C(F)C=C3)C4=CC=C(F)C=C4)CC2)C(OC)=C1OC.[H]Cl.[H]Cl
Molecular Formula
C27H32Cl2F2N2O3
Molecular Weight
541.46
Precautions
H302, H410
References & Citations
[1]Tran LT, et al. The voltage-gated calcium channel blocker Lomerizine is neuroprotective in motor neurons expressing mutant SOD1, but not TDP-43. J Neurochem. 2014 Aug;130 (3) :455-66.|[2]Zhu HJ, et al. [Reversal of multidrug resistance by Lomerizine in K562/ADM cells]. Yao Xue Xue Bao. 2004 May;39 (5) :333-7.|[3]Nakamura-Yanagidaira T, et al. Development of spontaneous neuropathy in NF-κBp50-deficient mice by calcineurin-signal involving impaired NF-κB activation. Mol Vis. 2011;17:2157-70.|[4]Shimazawa M, et al. Effects of Ca2+ channel blockers on cortical hypoperfusion and expression of c-Fos-like immunoreactivity after cortical spreading depression in rats. Br J Pharmacol. 1995 Aug;115 (8) :1359-68.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
L-type calcium channel; T-type calcium channel
Available Sizes
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