METTL1-WDR4-IN-2
METTL1-WDR4-IN-2, an adenosine derivative, is a selective methyltransferase Like 1 (METTL1) -WDR4 inhibitor with an IC50 of 41 μM. METTL1-WDR4-IN-2 shows selectivity against METTL3-14 (IC50 of 958 μM) and METTL16 (IC50 of 208 μM) . METTL1-WDR4-IN-2 can be used for the study of cancer[1].
Product Specifications
CAS Number
[2919742-07-5]
UNSPSC
12352005
Target
DNA Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mettl1-wdr4-in-2.html
Purity
99.71
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O[C@@H]1CSCC4=CC(C(O)=O)=CC(C5=CC=C(O)C=C5)=C4
Molecular Formula
C24H23N5O6S
Molecular Weight
509.53
References & Citations
[1]Nai F, et al. Small-Molecule Inhibitors of the m7G-RNA Writer METTL1. ACS Bio Med Chem Au. 2023 Dec 12;4 (2) :100-110.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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