10-Hydroxy-2-decenoic acid

10-Hydroxy-2-decenoic acid (10-HDA) is an orally active unsaturated medium-chain fatty acid with various physiological activities. 10-Hydroxy-2-decenoic acid induces ROS-mediated apoptosis in A549 cells. 10-Hydroxy-2-decenoic acid inhibits VEGF-induced angiogenesis in human venous endothelial cells. 10-Hydroxy-2-decenoic acid alleviates non-alcoholic fatty liver disease (NAFLD) by activating the AMPK-α signaling pathway. 10-Hydroxy-2-decenoic acid protects against bone loss by inhibiting NF-κB signaling downstream of FFAR4. 10-Hydroxy-2-decenoic acid is an antibiotic against many bacteria and fungi, such as Neurospora sitophila, molds and Staphylococcus aureus. 10-Hydroxy-2-decenoic acid has longevity-promoting effects in C. elegans. 10-Hydroxy-2-decenoic acid prevents osteoarthritis by targeting aspartyl β hydroxylase and inhibiting chondrocyte senescence[1][2][3][4][5][6][7][8][9][10].

Product Specifications

CAS Number

[765-01-5]

Product Name Alternative

10-HDA; Queen Bee Acid

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

AMPK; Apoptosis; Bacterial; Caspase; ERK; Fungal; GSK-3; Interleukin Related; MDM-2/p53; mTOR; NF-κB; TNF Receptor

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Epigenetics; Immunology/Inflammation; MAPK/ERK Pathway; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/10-hydroxy-2-decenoic-acid.html

Purity

99.99

Solubility

DMSO : ≥ 250 mg/mL

Smiles

O=C(O)/C=C/CCCCCCCO

Molecular Formula

C10H18O3

Molecular Weight

186.25

Precautions

H302, H315, H319, H335

References & Citations

[1]Geng N, et al.10-hydroxy-2-decenoic acid prevents osteoarthritis by targeting aspartyl β hydroxylase and inhibiting chondrocyte senescence in male mice preclinically. Nat Commun. 2024 Sep 4;15 (1) :7712.|[2]TOWNSEND GF, et al. Studies on the in vitro antitumor activity of fatty acids. I. 10-Hydroxy-2-decenoic acid from royal jelly. Cancer Res. 1960 May;20:503-10|[3]Tang M, et al. 10-Hydroxy-2-decenoic acid attenuates nonalcoholic fatty liver disease by activating AMPK-α signaling pathway. Biochem Pharmacol. 2025 Jan;231:116648.|[4]Han L, et al. 10-hydroxy-2-decenoic acid alleviates lipopolysaccharide-induced intestinal mucosal injury through anti-inflammatory, antioxidant, and gut microbiota modulation activities in chickens. Front Microbiol. 2023 Oct 17;14:1285299. |[5]Gao K, et al. Anti-Biofilm and Anti-Hemolysis Activities of 10-Hydroxy-2-decenoic Acid against Staphylococcus aureus. Molecules. 2022 Feb 22;27 (5) :1485.|[6]Gao K, et al. Anti-Biofilm and Anti-Hemolysis Activities of 10-Hydroxy-2-decenoic Acid against Staphylococcus aureus. Molecules. 2022 Feb 22;27 (5) :1485.|[7]BLUM MS, et al. 10-Hydroxy-delta 2-decenoic acid, an antibiotic found in royal jelly. Science. 1959 Aug 21;130 (3373) :452-3. |[8]Lin XM, et al. 10-HDA Induces ROS-Mediated Apoptosis in A549 Human Lung Cancer Cells by Regulating the MAPK, STAT3, NF-κB, and TGF-β1 Signaling Pathways. Biomed Res Int. 2020 Dec 8;2020:3042636. |[9]Honda Y, et al. Lifespan-extending effects of royal jelly and its related substances on the nematode Caenorhabditis elegans. PLoS One. 2011;6 (8) :e23527. |[10]Tsuchiya Y, et al. The key royal jelly component 10-hydroxy-2-decenoic acid protects against bone loss by inhibiting NF-κB signaling downstream of FFAR4. J Biol Chem. 2020 Aug 21;295 (34) :12224-12232.