Thalidomide-Piperazine-Piperidine (hydrochloride)

Thalidomide-Piperazine-Piperidine hydrochloride is a synthesized E3 ligase ligand-linker conjugate. Thalidomide-Piperazine-Piperidine hydrochloride incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

Product Specifications

CAS Number

[2599846-44-1]

UNSPSC

12352005

Target

Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/thalidomide-piperazine-piperidine-hydrochloride.html

Purity

98.41

Solubility

DMSO : 3.6 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 33.33 mg/mL (ultrasonic)

Smiles

O=C1NC(C(CC1)N2C(C3=CC=C(N4CCN(C5CCNCC5)CC4)C=C3C2=O)=O)=O.Cl

Molecular Formula

C22H28ClN5O4

Molecular Weight

461.94

References & Citations

[1]Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.