KLD-12 (TFA)
KLD-12 TFA is the TFA salt form of KLD-12. KLD-12 TFA is a self a 12-residue self-assembling peptide that is used in tissue-engineering. KLD-12 TFA combined with SDF-1 self-assembled polypeptide enhances chondrogenic differentiation of bone marrow stromal cells (BMSCs). KLD-12 TFA hydrogel can fill full-thickness osteochondral defects in situ and improve cartilage repair[1][2][3].
Product Specifications
UNSPSC
12352209
Target
Others
Type
Peptides
Related Pathways
Others
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/kld-12-tfa.html
Purity
95.22
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC(C)C[C@@H](C(N)=O)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H](CC(C)C)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC([C@H](CC(C)C)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@H](CCCCN)NC(C)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.O=C(O)C(F)(F)F.[x]
Molecular Formula
C68H122N16O19.xC2HF3O2
Molecular Weight
1467.79 (free base)
References & Citations
[1]Cao M, et al., Self-Assembled KLD-12/SDF-1 Polypeptide Promotes Differentiation and Migration of BMSCs via the Wnt/β-catenin Signaling Pathways. Protein Pept Lett. 2022;29 (10) :851-858. |[2]Tripathi JK, et al., Variants of self-assembling peptide, KLD-12 that show both rapid fracture healing and antimicrobial properties. Biomaterials. 2015 Jul;56:92-103. |[3]Kisiday J, Jet al., Self-assembling peptide hydrogel fosters chondrocyte extracellular matrix production and cell division: implications for cartilage tissue repair. Proc Natl Acad Sci U S A. 2002 Jul 23;99 (15) :9996-10001.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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