Necroptosis-IN-3
Necroptosis-IN-3 (Compound 69) is a necroptosis inhibitor that inhibits TNF-α induced necroptosis[1]. Necroptosis-IN-3 (Compound STX1638) also inhibits 11β-HSD1[2].
Product Specifications
CAS Number
[547698-18-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
11β-HSD; Necroptosis
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/necroptosis-in-3.html
Purity
99.53
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1CCCCC1)NCC2=CC=CS2
Molecular Formula
C12H17NOS
Molecular Weight
223.33
Precautions
H302, H315, H319, H335
References & Citations
[1]Junying Yuan, et al. Small molecule inhibitors of necroptosis. Patent US20120122889A1.|[2]Nigel Vicker, et al. Compound. Patent US20100120789A1.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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