Ifenprodil (tartrate)
Product Specifications
UNSPSC Description
Ifenprodil tartrate is a typical noncompetitive NMDA receptor antagonist. Ifenprodil tartrate exerts high affinity at NR1A/NR2B receptors (IC50=0.34 μM) over 400-fold than at NR1A/NR2A receptors (IC50=146 μM)[1]. Ifenprodil tartrate inhibits GIRK (Kir3), reduces inward currents through the basal GIRK activity. Ifenprodil tartrate has the potential to be a cerebral vasodilator[2].
Target Antigen
iGluR; Potassium Channel
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel;Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Ifenprodil-tartrate.html
Purity
99.95
Solubility
DMSO : ≥ 500 mg/mL|H2O : 5 mg/mL (ultrasonic)
Smiles
OC(C1=CC=C(O)C=C1)C(C)N(CC2)CCC2CC3=CC=CC=C3.O=C(O)[C@H](O)[C@@H](O)C(O)=O.[1/2]
Molecular Weight
400.49
References & Citations
[1]Williams K, et al. Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors. Mol Pharmacol. 1993 Oct;44(4):851-9.|[2]Kobayashi T, et al. Inhibition of G protein-activated inwardly rectifying K+ channels by ifenprodil. Neuropsychopharmacology. 2006 Mar;31(3):516-24.Antimicrob Agents Chemother. 2024 Oct 3:e0103524.|Chemosphere. 2019 Aug;229:618-630. |Eur J Pharmacol. 2023 Nov 6:176174.|Eur J Pharmacol. 2024 Jul 25:176860.|Exp Brain Res. 2023 Oct 16.|Pharmaceuticals (Basel). 2024 Sep 19;17(9):1234.|Chemosphere. 2019 Aug;229:618-630. |Heliyon. 2023 May 29, e16631.|Life Sci. 2022 Feb 17;295:120419.|Neurosci Bull. 2020 Feb;36(2):153-164.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12882A/Ifenprodil-tartrate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12882A/Ifenprodil-tartrate-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
23210-58-4
Available Sizes
Curated Selection
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