Ifenprodil (tartrate)
Ifenprodil (NP-120) tartrate, a cerebral vasodilator, is a noncompetitive NMDA receptor antagonist. Ifenprodil tartrate exerts high affinity at NR1A/NR2B receptors (IC50=0.34 μM) over 400-fold than at NR1A/NR2A receptors (IC50=146 μM) [1]. Ifenprodil tartrate is an α1 adrenergic receptor antagonist. Ifenprodil tartrate inhibits GIRK (Kir3), reduces inward currents through the basal GIRK activity. Ifenprodil tartrate has reliable inhibitory effects against A/H1N1 strains (EC50 of 6.6 µM) . Ifenprodil tartrate has neuroprotective, anticonvulsant and antinociceptive effects. Ifenprodil tartrate can be used for the study of cerebrovascular diseases and peripheral arterial obliterative disease[2][4].
Product Specifications
CAS Number
[23210-58-4]
Product Name Alternative
NP-120 (tartrate) ; RC-61-91 (tartrate)
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Adrenergic Receptor; Calcium Channel; iGluR; Influenza Virus; Potassium Channel
Type
Natural Products
Related Pathways
Anti-infection; GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Infection; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Ifenprodil-tartrate.html
Purity
99.95
Solubility
DMSO : ≥ 500 mg/mL|H2O : 5 mg/mL (ultrasonic)
Smiles
OC(C1=CC=C(O)C=C1)C(C)N(CC2)CCC2CC3=CC=CC=C3.O=C(O)[C@H](O)[C@@H](O)C(O)=O.[1/2]
Molecular Formula
C21H27NO2.1/2C4H6O6
Molecular Weight
400.49
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
NMDA Receptor
Citation 01
Available Sizes
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