Ezatiostat
Ezatiostat (TER199 free base; TLK199) is a tripeptide analog of glutathione and is a selective and orally active glutathione S-transferase P1-1 (GSTP1) inhibitor. Ezatiostat leads to JNK activation by inhibiting GSTP1. Ezatiostat stimulates both lymphocyte production and bone marrow progenitor proliferation. Ezatiostat has the potential for myelodysplastic syndrome (MDS) treatment[1][2].
Product Specifications
CAS Number
168682-53-9
Product Name Alternative
TER199 (free base) ; TLK199
UNSPSC
12352209
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Glutathione S-transferase
Type
Peptides
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ezatiostat.html
Purity
99.82
Solubility
DMSO : 100 mg/mL (ultrasonic) |Ethanol : ≥ 100 mg/mL
Smiles
O=C(OCC)[C@@H](C1=CC=CC=C1)NC([C@@H](NC(CC[C@H](N)C(OCC)=O)=O)CSCC2=CC=CC=C2)=O
Molecular Formula
C27H35N3O6S
Molecular Weight
529.65
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
Phase 2
Citation 01
Available Sizes
Frequently Asked Questions
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