JG-98
Product Specifications
UNSPSC Description
JG-98, an allosteric heat shock protein 70 (Hsp70) inhibitor, which binds tightly to a conserved site on Hsp70 and disrupts the Hsp70-Bag3 interaction. JG-98 shows anti-cancer activities affecting both cancer cells and tumor-associated macrophages[1][2][3].
Target Antigen
Apoptosis; HSP
Type
Reference compound
Related Pathways
Apoptosis;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jg-98.html
Purity
99.88
Solubility
DMSO : 5 mg/mL (ultrasonic)
Smiles
CN1/C(SC2=CC(Cl)=CC=C12)=C3S/C(N(CC)C\3=O)=C\C4=[N+](C=CS4)CC5=CC=CC=C5.[Cl-]
Molecular Weight
534.54
References & Citations
[1]Li X, et al. Analogs of the Allosteric Heat Shock Protein 70 (Hsp70) Inhibitor, MKT-077, as Anti-Cancer Agents. ACS Med Chem Lett. 2013 Nov 14;4(11).|[2]Li X, et al. Validation of the Hsp70-Bag3 protein-protein interaction as a potential therapeutic target in cancer. Mol Cancer Ther. 2015 Mar;14(3):642-8.|[3]Yaglom JA, et al. Cancer cell responses to Hsp70 inhibitor JG-98: Comparison with Hsp90 inhibitors and findingsynergistic drug combinations. Sci Rep. 2018 Feb 14;8(1):3010.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-117282/JG-98-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-117282/JG-98-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1456551-16-8
Available Sizes
Curated Selection
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