JG-98

JG-98, an allosteric heat shock protein 70 (Hsp70) inhibitor, which binds tightly to a conserved site on Hsp70 and disrupts the Hsp70-Bag3 interaction. JG-98 shows anti-cancer activities affecting both cancer cells and tumor-associated macrophages[1][2][3].

Product Specifications

CAS Number

[1456551-16-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; HSP

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/jg-98.html

Purity

99.88

Solubility

DMSO : 5 mg/mL (ultrasonic)

Smiles

CN1/C(SC2=CC(Cl)=CC=C12)=C3S/C(N(CC)C\3=O)=C\C4=[N+](C=CS4)CC5=CC=CC=C5.[Cl-]

Molecular Formula

C24H21Cl2N3OS3

Molecular Weight

534.54

Precautions

H302, H315, H319, H335

References & Citations

[1]Li X, et al. Analogs of the Allosteric Heat Shock Protein 70 (Hsp70) Inhibitor, MKT-077, as Anti-Cancer Agents. ACS Med Chem Lett. 2013 Nov 14;4 (11) .|[2]Li X, et al. Validation of the Hsp70-Bag3 protein-protein interaction as a potential therapeutic target in cancer. Mol Cancer Ther. 2015 Mar;14 (3) :642-8.|[3]Yaglom JA, et al. Cancer cell responses to Hsp70 inhibitor JG-98: Comparison with Hsp90 inhibitors and findingsynergistic drug combinations. Sci Rep. 2018 Feb 14;8 (1) :3010.