Naloxone methiodide

Naloxone methiodide is a peripherally restricted, nonselective, and competitive opioid receptor antagonist. Naloxone methiodide does not penetrate the blood-brain barrier[1][2].

Product Specifications

CAS Number

[93302-47-7]

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Opioid Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/naloxone-methiodide.html

Purity

99.7

Solubility

DMSO : 250 mg/mL (ultrasonic) |H2O : 25 mg/mL (ultrasonic)

Smiles

O[C@@]1(CCC2=O)[C@@]([C@@]2([H])OC3=C4O)(CC5)C3=C(C=C4)C[C@H]1[N@@+]5(C)CC=C.[I-]

Molecular Formula

C20H24INO4

Molecular Weight

469.31

Precautions

H315, H319, H335

References & Citations

[1]Basso L, et al. TRPV1 promotes opioid analgesia during inflammation. Sci Signal. 2019;12 (575) :eaav0711. Published 2019 Apr 2. |[2]Basso L, et al. Endogenous control of inflammatory visceral pain by T cell-derived opioids in IL-10-deficient mice. Neurogastroenterol Motil. 2020;32 (2) :e13743.