NKH477

NKH477 (Colforsin dapropate hydrochloride) directly activates the catalytic unit of adenylate cyclase and increases intracellular cAMP. NKH477 is a forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 exerts an antiproliferative effect in vivo with an altered cytokine profile to inhibit the acute rejection of rat orthotopic lung allografts[1].

Product Specifications

CAS Number

[138605-00-2]

Product Name Alternative

Colforsin dapropate hydrochloride

UNSPSC

12352005

Hazard Statement

H300

Target

Adenylate Cyclase

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/nkh477.html

Purity

99.86

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 20 mg/mL (ultrasonic)

Smiles

O[C@@]12[C@@]3([C@@](C(C)(CC[C@@H]3O)C)([H])[C@H](OC(CCN(C)C)=O)[C@H](OC(C)=O)[C@]1(O[C@](C=C)(C)CC2=O)C)C.Cl

Molecular Formula

C27H44ClNO8

Molecular Weight

546.09

Precautions

H300

References & Citations

[1]Nakashima S, et al. Antiproliferative effects of NKH477, a forskolin derivative, on cytokine profile in rat lung allografts. J Heart Lung Transplant. 2005 Apr;24 (4) :462-9.