NKH477
NKH477 (Colforsin dapropate hydrochloride) directly activates the catalytic unit of adenylate cyclase and increases intracellular cAMP. NKH477 is a forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 exerts an antiproliferative effect in vivo with an altered cytokine profile to inhibit the acute rejection of rat orthotopic lung allografts[1].
Product Specifications
CAS Number
[138605-00-2]
Product Name Alternative
Colforsin dapropate hydrochloride
UNSPSC
12352005
Hazard Statement
H300
Target
Adenylate Cyclase
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/nkh477.html
Purity
99.86
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 20 mg/mL (ultrasonic)
Smiles
O[C@@]12[C@@]3([C@@](C(C)(CC[C@@H]3O)C)([H])[C@H](OC(CCN(C)C)=O)[C@H](OC(C)=O)[C@]1(O[C@](C=C)(C)CC2=O)C)C.Cl
Molecular Formula
C27H44ClNO8
Molecular Weight
546.09
Precautions
H300
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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ALG2, ID (ALG2, Alpha-1,3/1,6-mannosyltransferase ALG2, Asparagine-linked glycosylation protein 2 homolog, GDP-Man:Man (1) GlcNAc (2) -PP-Dol alpha-1,3-mannosyltransferase, GDP-Man:Man (1) GlcNAc (2) -PP-dolichol mannosyltransferase, GDP-Man:Man (2) GlcNAc (2) -PP-Dol alpha-1,6-mannosyltransferase) (FITC) discontinued
