ALK5-IN-8
ALK5-IN-8 is a potent inhibitor of TGFβRI (ALK5) . ALK5-IN-8 Inhibits the phosphorylation of ALK5 on its downstream signaling proteins (Smad2 or Smad3) by blocking the binding of TGFβRI to ligands, thereby affecting or blocking TGF-β signaling. ALK5-IN-8 has the potential for the research of various ALK5-mediated related diseases (extracted from patent WO2021190425A1, compound 1) [1].
Product Specifications
CAS Number
[2705900-81-6]
UNSPSC
12352005
Target
TGF-β Receptor
Type
Reference compound
Related Pathways
TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/alk5-in-8.html
Concentration
10mM
Purity
98.21
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(C1=C2C=C(C3=CNN=C3C4=CC=C(F)C=C4)C=CN2N=C1)OCC
Molecular Formula
C19H15FN4O2
Molecular Weight
350.35
References & Citations
[1] Zhiyong Yu, et al. Transforming growth factor-beta receptor inhibitor. Patent WO2021190425A1.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
Tnks 2, CT (TNKS2, PARP5B, TANK2, TNKL, Tankyrase-2, ADP-ribosyltransferase diphtheria toxin-like 6, Poly [ADP-ribose] polymerase 5B, TNKS-2, TRF1-interacting ankyrin-related ADP-ribose polymerase 2, Tankyrase II, Tankyrase-like protein, Tankyrase-related
Tnks 2, CT (TNKS2, PARP5B, TANK2, TNKL, Tankyrase-2, ADP-ribosyltransferase diphtheria toxin-like 6, Poly [ADP-ribose] polymerase 5B, TNKS-2, TRF1-interacting ankyrin-related ADP-ribose polymerase 2, Tankyrase II, Tankyrase-like protein, Tankyrase-related
Human Lung Parenchymal Fibroblasts (Pulmonary Arterial Hypertension, PAH)
